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A misspelling of guido, which is a pejorative term applied to certain Italian-American males.
Guy 1: Joey Spagnola? He's a total gweedo.

Guy 2: Dude, it's spelled "guido".

Guy 1: Oh.
gweedo by joeySP January 10, 2009
Related Words

gweedo tuxedo 

A track suit, preferably Adidas or Puma, and wife beater worn by a gweedo (Italian from Jersey). Gweedo's think they have good style, but they are wrong.
The guy from Jersey was such a badass, he was buried in his gweedo tuxedo.
gweedo tuxedo by SmokeyJoe1500 February 11, 2008
A wigger that dresses like one of the Sopranos.
"Who's that guy in the track-suit with the greasy hair?"
"Some fuckin' gweedo!"
"Someone should tell 'em to lay off the cologne."
gweedo by twobitp December 29, 2006
the act of two people putting their buttholes together while having sexual intercourse and droppin a steamy pickle (Shit) in eachothers bung holes.
I was watching Full House all day and Bob Saget gave me the urge to have a sloppy gweedo session with my girlfriend.
gweedo by Ignacio Dumpington February 21, 2009

Gweedore 

Possibly one of the best places in Ireland. Gweedore is located in County Donegal and Gaelic (Irish) is the main language spoken there, lovely beaches, great place all together
Ta me i mo chonai ina Goith dobhair!
... I live in Gweedore
Gweedore by Mr toto January 23, 2009
A slight mustache that looks horrible but the person who has it is extremely proud of it. It is made of peach fuzz and is just hairy enough to look disgusting.
Phil's gweedo stache made me want to throw up.
Gweedo by Pierre von Stoiben October 7, 2005