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go off, I guess 

Sort of like "you do you," but with a strong implication that you're talking out of your ass. Basically "you're an idiot and what you're saying is stupid, if you want to keep going I guess I won't stop you."
Bob: "The world is run by lizard people."

Sue: "There's no such thing as lizard people, but go off, I guess."
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guessmile 

(verb) - when you didn't understand what someone said and don't want to ask them to repeat themselves multiple times and just guess that they said something funny and smile.
It was way too loud to make out what he was saying so I just guessmiled at him
guessmile by Danlod2 April 27, 2018

Guesseneuh 

Someone that is always confused with what's going on.
Pronounced as guess een nee uh
"Hey Guesseneuh!', said Bob
"What?" replied John

guess i'll just go fuck myself 

When somebody ignores/pretends you don't exist. Almost as if they're telling you to go fuck yourself, but without actually saying it.
Person 1: Hey there! How are you doing?
Person 2: ...
Person 1: Soo.... what's up?
Person 2: ...
Person 1: Well I guess i'll just go fuck myself, then.

I guess you had to be there 

What you say when someone tells you something he thinks is hilarious but really isn't. You say this to avoid hurting your friend's feelings in breaking it to him that his joke sucks.
Dudeman 1: "Oh man, I was playing horseshoes in Red Dead Redemption and I got a really close throw and John was all like, 'Did you see that!' It was so funny dude!"

Dudeman 2: "I guess you had to be there."

Dudeman 1: :(

Uh, that's a good guess 

something teachers, grown-ups, or coaches say when you got an answer SUPER wrong but they don't want to discourage you
me: *looks at DNA* "is that a roman column"
teacher: Uh, that's a good guess

Guess What's In My Pants

A game played on the "Opie and Anthony" radio show in which female callers are asked to rub their phone against their most intimate of areas in a variety of motions(up and down, side to side,circular motion) and then guess the particular hair style the woman is sporting. Styles include wood floor or john bennet, the landing strip, the hitler mustache, the earth momma muff, and the 5 o clock shadow.
Guess what's in my pants is another example of why Opie and Anthony are a much better radio show than that prick Howard Stern.