When a really ugly and/or nerdy and/or fat and/or smelly person invades your personal space and wants to intimately get to know you.
"OH look at poor Sue. that really ugly fat guy with zits erupting all over his face has pressed her into a corner and is trying to grope her. We'd better do a rescue mission because he's getting up gross and personal."
by Scarlett.007 February 6, 2010
Get the up gross and personal mug.