to annoy or bother someone to the point where they can't stand it anymore. Related to 'getting shitty' with someone or something. Similar to annoying the crap out of someone or driving them up the wall.

Also sometimes used to refer to a case of diarrhoea or 'the runs' or 'the trots'.
Stop it Barry, you're giving me the shits!
This thing gives me the shits.
Watch it, I'm starting to get the shits with you mate!
This job really gives me the shits.
by referencedesk May 11, 2015
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