look up any word, like thot:
GFS is known as "Greg Fox Syndrome," and originates from GFox at the newsgroup alt.games.final-fantasy. It means taking an innocent statement, and making it as perverted as possible.

There is also GFSblock and GFSbait.
Low level wizard: "Anybody have a cheap rod?"
Some other guy: "Anyone care to GFS that?"
by LockeZ March 13, 2004
Gay Family Shit
Used when your plans are ruined by family obligations.
"I got screwed into some GFS"
also popular is GGFS (Gay Girl Friend Shit)
by DS June 07, 2004