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1.
Something that is extremely messed up.
His teeth are so ganked up.
by geogirl August 01, 2008
15 1
 
2.
The slang term for tripping off DXM (Dextromethorphan). The trip from DXM is intense. Theres about a 50% chance of what type of high you will have either you will trip the fuck out but be able to converse with others. Or you will be completely dissociative in your own little world lol good luck!!!
Im All Ganked Up Homie!

You see that fool? He looks ganked up!
by The Green Wave September 01, 2009
4 1