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1.
What the fuck is up?
Yo diddy, fucksup wit you today?
by LouWho March 01, 2008
 
2.
1.) A more refined way of saying "What the fuck is up?"

2.) A common Michigander greeting.
Fred: Hey Bitch. Fuck's up?
Sally: Not too much.
by BSliggs June 26, 2011
 
3.
A different variation of a widely used term,"What's up?"
Person 1: Hey, John.

Person 2: Fuck's up?
Person 1: Not much.
Person 2: Cool, real cool...
by Hellomynameis_______..... December 07, 2010