1) A phrase of agreement. Used when responding to a statement.

2) Another way of saying, "Of course." Used when responding to a yes/no question.

Both are heard in mostly urban areas, especially ghettos. Either that, or heard in an SUV driven by some white, suburban kid listening to rap.
1) Rodney: That was a great party last night!
Samuel: Fo shizzle ma nizzle!

2) Herman: Was that party last night great, or what?
Helga: Fo shizzle ma nizzle.

By the way, it appears many of the people who defined this word don't like black people. You might say that Rodney Basil doesn't like suburban, white people, but that's not so. I am a suburban, white person.
by Rodney Basil April 25, 2004
Get the Fo Shizzle ma Nizzle mug.
for sure my --insert colloquial expletive beginning with "n"-- .

Just to clarify... The "izzles" and "izzos" were introduced to urban pop culture by Double Dutch Bus in 1981, however, Snoop took it to a new level. Snoop interpolated Double Dutch Bus (which was written by Bill Bloom and Frankie Smith) and originally performed by Frankie Smith (NOT the Gap Band).
Dizzouble Dizzutch... Double Dutch.
by ebloom November 8, 2004
Get the fo shizzle ma nizzle mug.
"fo shizzle ma nizzle" is a bastardization of "fo' sheezy mah neezy" which is a bastardization of "for sure mah nigga" which is a bastdardization of "I concur with you whole heartedly my African american brother"
by pixelfrenzy April 15, 2009
Get the Fo shizzle ma nizzle mug.
Said in an over dramatised accent, Used as an exclamation.

Actually means "shit my nigger" although not used in that context in this case.
"will you come over here and look at this?"
on looking:
"Shizzle ma Nizzle!"
by General Spoon April 16, 2008
Get the Shizzle ma Nizzle mug.
A modification of the English language, generally used to give birth to cultural identity where none previously existed. The process can be compared to the creation of Frankenstein from bits and pieces of other organisms.

See also: Narcissism
Normal Individual: "Hey, want to head to the bar later?"
Cultural Narcissist: "Fo' shizzle ma nizzle!"
(absolutely!)

Normal Individual: "Uhm, alright. How's 8 sound?"
Cultural Narcissist: "Wu dazzle in da hoozy baloozy, bling bling bling!"
(*translation unknown*)

Normal Individual: "I didn't understand a word of that."
Cultural Narcissist: "Fo' shizzle yo!"
(that's because you're inferior and I'm not)

"It was already one in the morning; the rain pattered dismally against the panes, and my candle was nearly burnt out, when, by the glimmer of the half-extinguished light, I saw the dull yellow eye of the creature open . . ." -Frankenstein, by Mary Shelley
by Barnaebus November 15, 2010
Get the fo' shizzle ma nizzle mug.