1.When something is messed up,tangled up, or broken;possibly beyond repair. Can be used as an alternative to "fucked up"; esp. useful if you have small children.
2.The state of mental confusion arising from emotional distress or exhaustion,also a result of the use of cold medicine.
"Why are my Ipod headphones always all fishmeckled?"
"Andrew was feeling fishmeckled after taking Nyquil for his cold."
fucked up messed up tangled up broken trashed fubar beat confused loopy ditzy spaced out medicine head destroyed