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2.
You're exhausted because your real life can't keep up with your virtual one.
Friend: "I sent you a Facebook message and never heard back. What up?"

You: "Sorry, man. I have a serious case of Facebook Fatigue. The doc says I need hot tea, fresh air and to practice looking into the distance at least 3x a day."
by trailer y February 05, 2011
 
1.
The condition of being bored with facebook.
I haven't updated my Facebook profile in months. I have facebook fatigue.
by circushead March 07, 2008