Top Definition
A divine medication that does the impossible over several years; it acts like estrogen and gives the transgendered woman (MTF)the body of a real woman by redistributing body fat, giving her breasts, reducing muscle mass, and making that stupid phallus thing that she has between her legs finally STFU and stay small for good. However, estradiol will not change beard hair or voice pitch.
Jake: Hey Carly!!!! You're looking mighty womanly now, last time I saw you you looked like a manshe. Must be the estradiol you've been taking; oh and OMG can I feel your boobs pls???!!!

Carly: No, you may not feel my b-cup breasts!!!
by Jsybuurd December 30, 2008

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