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1.
After watching an epic movie or TV series, or playing an epic video game, the feeling of depression or dissatisfaction with one's real life in comparison to the awesomeness of what one saw/lived on screen, i.e. "my life can never be that awesome oh god." Epic, in this case, meaning circumstances that lead the protagonist to save the world or live life in a way that nobody could remotely approach in reality.

Usually lasts 1-5 days after the conclusion of said epic movie/series/game.
"How fucking amazing would it be if I could get really ripped and fight crime like Batman....oh god damn it, it's basically impossible. I'm going to spend the next 30 years in a cubicle trying to get the office that's slightly bigger than a cubicle. My life is so fucking boring and background and I'll never realize my dreams. I have such a severe case of epic movie syndrome that I might as well kill myself."
by Superking April 30, 2012