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When your ego dies.

Usually one can only do this after years of meditating and learning about their own ego to eventually attain and maintain enlightenment.

You can also kill your ego by taking large amounts of LSD, mushrooms, mescaline, peyote or DMT....

Although the effects wear off.

Your ego is explained by Buddhism...

Your ego is deeply attached and saturated with your personality and your identity.
Last night I drank some ayahuasca and I felt like I was dying! In actuality it was just my ego dying aka egocide.

Americans need mass egocide. Let's put LSD in the water.
egocide by Frank Nutz March 11, 2017
Related Words

egocision 

A decision based on ego rather than fact, past history or knowledge of the matter.
All the knowledgeable staff were fired due to the bosses egocision.
egocision by SickMontanan November 23, 2015
The action of going to the gym, not to workout as such, but to peacock around the weight lifting areas, standing in front of the mirror pulling poses, flexing here and there, walking around (like you are carrying a wheelbarrow) shaking your fellow gym buddy hand's, chatting, and attempting to pick-up the opposite sex. Usually attending the gym for many many hours at a time such egocisors are usually found congregating in groups of two or three, primarily locating themselves around the most popular equipment (or area with the most mirrors) during peak hour. Talking loud, slapping each other, making unnecessary grunting noise during the act of lifting weights (when they actually getting around to doing so).
John: Who's that super buff tanned bloke that just came and shook my hand like he was my long lost mate!?

Steve: Oh he's here every time I come! He's just doing his egocising warm up routine. Oh and look at that - his buddy who must have already done the rounds is over there right now tuning your girlfriend on the treadmill!
Egocising by watsonism August 22, 2012
Unlike pesticide, or homicide or suicide or genocide, egocide is an immaterial but no less serious form of ciding, and happens undercover all the time. There are multiple ways to commit egocide, the most common being (as mentioned by another dictioneerist, jpg3) simply devaluing yourself and having chronic low self-esteem. However, this is a slow process, and - by the way - egocide is not merely a form of suicidal behavior- more egocide is committed against an other ego rather than one's own. This is basically the competitive side of human nature, the meanness and cutthroat behavior which flourishes in toxic environments such as office buildings and rich people's homes. (see sociopathy)

That said, the more radical form of egocide is the one committed by the selfsame ego, which happens in traumatic experiences or abuse of hallucinogenic or psychotropic drugs (psilocybin, lsd, etc), a chemically-induced wiping away of the frail scraps of the ego in the deluge of traumatic experience. Technically the ego can't die, except through Buddhist practice (in which it is simply overcome), but it can be buried underneath the heap of psychic distress which encapsulates the traumatic event.

Egocide is very painful but meditation is a good remedy for its potentially adverse affects.
I've committed egocide so many times I can't even de-cide what to leggo my eggo with anymore
egocide by Pincetti September 8, 2019
The act of dying while taking an extreme selfie.
The dude on top of the building committed egocide!
egocide by Magna Vaqua November 6, 2015
Ego + expertise, when an individual thinks they have expertise in a subject but it is driven by their huge ego. In reality they don’t have knowledge on the topic but think they should give their opinion.
Person 1: Wow Frank really knows his stuff about fine wines.

Person 2: I think it’s his egotise.
egotise by SweetOneTime December 19, 2021