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1.
The perceived loss of boundaries between self and environment

a possible effect of LSD, special K, shrooms, and mescaline among others
My ego death completely changed my life.
by Sourbs March 14, 2007
 
2.
A complete loss of ego and self-worth, generally occuring during the use of psychedelics. (ie. LSD, Marijuana, Ketamine, mushrooms, salvia)
My ego death last night was harsh, i thought i was worthless, i questioned my life all together.
by ConnorM June 10, 2008