Horny furry: uwu i jewk off to pown on e621
Normal guy: yo I dare you to get a life
by Renewings January 12, 2022
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I’m sorry Jase, but why do you have 3 tabs of e621 on your browser
by CurledPawsAndStuff January 22, 2023
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e621 is a furry website that if your not a Furry then DONT ENTER THE WEBSITE… UNLESS YOUR A FURRY
UwU I like e621
by Mangoodmonkegood June 22, 2023
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Some random furry hentai shit that is like r34.xxx but worse (or better depending on who you are)
Man 1: I personally believe r34.xxx is better than e621.net
Man 2: e621.net is the best website whenever i'm horny asf and dont give a shit about which porn i see
Man 1: So does that include child porn?
Man 2: NO THATS NOT WHAT I MEANT-
by LFoxer May 30, 2023
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It's the E number for Monosodium Glutamate (aka MSG).

The furry imageboard with the same name most likely named itself E621 to address how 'tasty' their content is.

Funnily enough, there's a forum named E926 (the E number for bleach) that exists as an eye-bleach after one views the 'tasty' content of E621.
Person 1: E621 is love, E621 is life

Person 2: Ew, miss me with that furry shit
by Obv troll is obvious March 23, 2021
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E-number for Monosodium Glutamate, a common food additive that has a distinct umami taste.

Also refers to a particular website...
Alice: E621 tastes really good!
John: What's E621?
Alice: You'll soon find out...
by レム July 23, 2020
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1. (n) Monosodium glutamate (MSG), a type of food additive.
2. (n) A website which is made mostly for furry pornography art.
Customer: Hey waiter, did you add E621 in my dish?
Waiter: What? No! Where do you see porn art in your steak?
Customer: Not that kind of e621, I talking about the additives- wait how do you know it’s furry porn?
Waiter: Ummmmmm fuck you.
Chef: WHERES MY FUCKING LAMB SAUCE
by DBS dude March 30, 2022
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