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1.
A drug substance derived from opiates, with a high amount of fatalities when used.
"Hey bro, wanna smoke some dtuff?"
"nahh man, didn't you hear about the kid who died from that last week?
by angrymanondrugs May 19, 2010
 
2.
A great website used for advertising in New Zealand
Hey man I just advertised on Dtuff.co.nz
by Reef Urban September 02, 2014