to be in agreement with someone or something, to be down with something
"yo bro, Im totally Im going to the rave tonight, you downzo?
by rog pennappleton January 17, 2008
A friend who acts stupid and is stupid, usually sharing characteristics of someone with mental illness, but is in fact not mental.
Hey, downzo, that was stupid!
by Taylor "Downso" Reagan August 02, 2008
the act of oral sex with your partner
Hey dude you wanna go downzo on each other?
by rog pennappleton January 17, 2008

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