Labeling a person with the ability to get drunk on minimal alcohol. Usually ends up acting the most drunk from complete non-tolerance to alcohol. Can be used to define a male/female who pukes after 15 minutes of drinking.
The combination of the first part of dude that makes the do sound and man which is changed to sound mane (like a lions mane) for more effectiveness in speech. Not meant to be derogatory. It can be used as a greeting like "Dude!" or as a replacement for a name (see examples).