A sound effect made by someone to emphasize when something is hit with high impact of any kind, be it a punch, a car slamming into a brick wall, a gunshot, or a high impact fart launching out of someones tight rectum with the force of ten typhoons.

You usually want to stretch out the "F" sound, as if it's a sniper rifle shot resonating through the air.
"Yo what's 'doof'? You keep saying that and it's confusing me."
"Oh! Allow me to demonstrate" *winds up punch and slams fist into their face* "DOOOOOOOOF"
by fartsensei69 January 24, 2020
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A person who is a straight up doof schmoof who loves to eat ass and play fortnite.
Danny has the biggest doof poop who loves to schnob on a cob..
by Dirk is Sleep May 11, 2018
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Doof is a slang term often used to describe a state of being under the influence of mind-altering substances, particularly when one is high or stoned. This word is commonly employed in informal conversations, typically in situations where someone appears to be acting in a carefree, goofy, or eccentric manner due to the effects of substances like marijuana or other recreational drugs. "Doofed" individuals might display altered perceptions, giggling fits, and a tendency to engage in quirky behavior, making it a fitting term to capture the lighthearted and sometimes offbeat nature of being in an altered state. However, it's important to note that the word "doof" is primarily used within specific social circles and might not be universally recognized.
“Bro i’m so doof I can’t believe this”

“How doof are you right now? I’m feeling pretty doof”
by yanguwan October 12, 2023
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“i just doofed” -bryce
“what does doof mean”-ava
“balloon deflating sound came out my peen”-bryce
“show me how”-ava
by hehehehehehehehh April 9, 2021
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The attempt to consume drugs with your dick. A dick-based boof. May be performed by dipping the tip in, pouching in the foreskin, funneling into urethra, among other methods.
It's free if you doof it!

Hey man be careful not to sniff coke from the doofin pile
by Doofer Dan January 13, 2023
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A ugly person who post pics of them on social media and thinks it’s cute
hey look at what noah posted what a doofing
by xoxololl March 28, 2020
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