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I dont fuck with that shit 

When you don't wanna do something because that's not how you are.
some friend: "Hey , you wanna smoke this joint with three kind of plants?"

You: "Nah bro, I dont fuck with that shit."

DONT YOU FUCK WITH MY DICK 

Abbreviated DYFWMD, this is a phrase commonly used in place of "don't mess with me", but with a more traditional meaning of "leave my penis alone".

This saying is thought to have been originated by Duke Wellington III, after a fellow nobleman who was stricken by the Black Plague, would use his decaying hand to taunt and otherwise pester the Duke. While this was primarily in jest, after the nobleman threatened to grab Wellington's scrotum (in effect, making it fall off), Wellington fatefully proclaimed "DONT YOU FUCK WITH MY DICK!" -- then proceeded to unsheathe his rapier and chop off the nobleman's infected hand.

True to it origins, this phrase is commonly followed by an act of aggression or violence.
Masculine Form - Contemporary

Dude 1: "Hey, I'm drinking your last beer…
Dude 2: "DONT YOU FUCK WITH MY DICK!" (punches Dude 1 in the head)

Masculine Form - Traditional

Dude 1: "Give me the remote or I’ll punch you in the balls.”
Dude 2: "DONT YOU FUCK WITH MY DICK!" (punches Dude 1 in the head)

Feminine Form

Girl 1: "Damn, that's your boyfriend...he's sexy! Does he like blondes?"
Girl 2: "DONT YOU FUCK WITH MY DICK!" (punches Girl 1 in the vagina)
DONT YOU FUCK WITH MY DICK by munkman September 19, 2011

dont fuck rock pussy with Glasscock 

an idiom warning to be aware of ones vulnerabilities and limitations and to avoid self-sabotaging situations. The idiom draws inspiration from 'dont throw bricks in a glass house' and Jack Glasscock-- a 20th century American baseball player who himself coined the phrase 'Charley Horse'.
You're literally the most socially anxious person I know, I dont know why you keep doing these speed-dating events. You know what they say, Dont fuck rock pussy with Glasscock.

I don't fuck with you 

Wanting nothing to do with someone, whether as a friend/acquaintance or more. Can be abbreviated as "idfwy" or "idfwu". Gained popularity from Big Sean's song. Not to be confused with the sexual meaning of "fucking someone".
Kacey: Hey why don't we invite Lisa to the party?
Marissa: Hell no. I don't fuck with her, she's annoying

Jason: Hey baby I miss you, let's get back together
Kacey: No thanks, I don't fuck with you

Don't fuck with me 

A request to not be bothered. Usually a more angered one and threathening one.
Don't fuck with me by CurlyHayami September 9, 2004

don't fuck with the payroll 

don't sleep with anyone in the workplace. Doing so may cause awkward encounters at work and your colleagues thinking you're easy.
I told you don't fuck with the payroll Jacky