It means: "Don't annoy me." "Don't make me angry." It's something you'd say to someone who was bugging you, or teasing you, or otherwise getting on your nerves---warning them that you might lose your temper and respond in a way they won't like.
-Hey, Why are you drinking so much, dude?
-Don't mess with me.
by EverPino1D November 11, 2015
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The true meaning of this phrase: It's an ANTI-LITTERING ADVERTISING CAMPAIGN started by the Texas Department of Transportation! See www (dot) dontmesswithtexas (dot) org.
It's an anti-littering campaign that has helped remove trash from Texas roadways by reminding people to clean up after themselves, so don't mess with Texas or you'll get a huge fine!
by Txgirl December 29, 2007
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It actually is a phrase that means the same as "Give A Hoot, Don't Pollute". It is on "Do not litter" signs in the state of Texas.
Man reading sign: Don't mess with Texas.
Other guy: What the fuck does that mean?
Man: I'm not sure, but I don't think we should be throwing these dead bodies here by the look of this sign. It says littering is a $500 fine.
Other guy: Shit.
by Syrupsippa October 8, 2010
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A phrase in which "big men" from Texas (see George W. Bush) will use in defense of their state.

Little do they know that it was a slogan coined in the 1960s by Ladybird Johnson in a highway beautificatoin campaign. So when you hear some macho cowboy say this, what they mean is "Please dont litter in my state."
I'll mess with Texas all I want! I just won't defenestrate my garbage.
by JakeStar April 22, 2005
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Yuppie greasers who walk like chicken arses and think they're tough shit in their Gucci tees. Their catch phrase.
by FulhamGardensPS September 24, 2013
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A polite way of saying that you don't have, and don't want to have, anything to do with someone or something.
I don't mess with Matt Lauer or the Today Show ... and that's a very nice way for me to put it!

I want to say one thing to the American people. I want you to listen to me. I'm going to say this again: I don't mess with that woman.
by Philosophistry November 15, 2010
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Something that a typical Texan will say...anyone "messing" with Texas is an impossibality because states are not allowed to have conflicts with other states let alone foreign countries...you dumbshits
by asdfsa October 7, 2006
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