Top Definition
The disturbing transformation of a familiar habitat (hangout) by a sudden zerg of non-indigenous groups (douche-bags, immigrants).
1. Jim and Ed no longer went dancing on Fridays at their local gay bar because it had become discompopulated by straight college kids who loved DJ Cumshot.

2. "No way I'm going to the that discompopulated Water Park, it's just Mexicans and Somalis and their gazillion kids."
by deemann October 30, 2011

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