Top Definition
To make something feel tighter, such as a vagina, screws, orange juice lids and vaginas.
1. Slim Bavis made the big switch to Tropicana from Minute Maid Orange Juice, because he was unable to de-loosify the lid.

2. Dan Jewell's large member has pulverized many vaginas, causing them to resort to Vaginercises which in turn will de-loosify that nappy dugout.
by Dan Jewell March 24, 2005
2 Words related to de-loosify

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