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Acronym for don't disturb the beast. Ddtb is used when you're so pissed off, tired, hungry (or all of the above) that you could literally curb stomp a puppy into the ground. It's a sign of fair warning.
Lauren: Hey bro! Just had the best day everr!! How are you?

David: I haven't slept in 48 hours, ddtb.
by athreemuskette July 28, 2011