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2.
exagerated or excited agreement with what somebody has just said
comin out for a biff?
Course!
by tee August 14, 2005
 
1.
In summation, simply "Murphy's Law".

Any of certain humorous axioms stating that anything that can possibly go wrong, will go wrong.
"Oh my god, its pouring outside"
"COURSE!....I just removed my umbrella from my backseat yesterday after it had sat there for 2 months without any use!"
by reevstar November 30, 2005
 
3.
Used with a repeated 'o' sound to express extreme sarcasm or blatant disregard
Someone: Blah blah blah do this
Me/You: COOOOOOOOOOOOOOOOOSE
by M:Dubs February 02, 2004
 
4.
Course means harsh, uncomforting often refering to something or someone that is unpleasant. Its most common use is in reference to violence or anger.
He carried on course. I will course you up. The weather out there is course. He is a course brother.
by Shion February 06, 2004