When playing a first person shooter, such as Call of Duty. One sneaks upon an unknowing victim, aims down sights through a scope at their anus/colon, and fires bullets relentlessly till the person dies.
"I was playing COD this afternoon when i snuck up on a newb and colonoscoped him."

"Aw man! that dude gave me a colonoscope"
by nolanoscopy October 29, 2014
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the act of a male having butt sex with a female, and then rinsing out her butt with your urine in preparation of butt sex.
"My girl told me to stick it in her ass, so i gave her a colonsoscopeee first."

"I gave Luckie a colonoscopee before i butt raped him because he would not let me spit in his butthole."
by corn up your crank January 8, 2012
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