Top Definition
The sibling symptom to montezumas revenge, but far far worse and more excruciating.

It occours several hours after consuming food which is caked with hot peppers, especially cheyanne pepper.

Symptoms of cheyannes revenge include but are not limited to: brutal shitting, grabbing ankle (see definition) excruciating pain and suicide.
Guy 1: (on toilet screaming)

Guy 2: Are you okay in there?

Guy 1: (screams) CHEYANNES REVENGE!
by J.P. The Last Brave Bishop February 17, 2009
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