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1.
sores caused by syphilis (Sexually Transmitted Disease)...generally quite skanky...
Woah check out that Chancre!
by Zojase October 20, 2001
 
2.
adjective: someone who is like a pestering disease; a person who always nags you and won't go away; someone who is so disgusting and repulsive that you would compare them to an STI

often used in a derogatory way towards someone who is acting like a tool.
Teri is such a chancre.

You are acting like a chancre!

That kid looks like a chancre.

I can't believe Bob is dating that chancre!
by Microkid April 16, 2010