sores caused by syphilis (Sexually Transmitted Disease)...generally quite skanky...
Woah check out that Chancre!
adjective: someone who is like a pestering disease; a person who always nags you and won't go away; someone who is so disgusting and repulsive that you would compare them to an STI
often used in a derogatory way towards someone who is acting like a tool.
Teri is such a chancre.
You are acting like a chancre!
That kid looks like a chancre.
I can't believe Bob is dating that chancre!