Top Definition
One of H.P Lovecraft's best known short stories. It was instrumental in forming what is now known as the Cthulhu Mythos. It is also the only story written by Lovecraft where Cthulhu makes an appearance.

Call of Cthulhu, is also the title of a popular pen-and-paper roleplaying game based on the Cthulhu Mythos that is published by Chaosium Inc.
"Have you read the short story Call of Cthulhu?"

"Last nights Call of Cthulhu gaming session was exciting, too bad you missed it."
by DavionShores September 12, 2005
The sudden, violent urge to spew forth diarrhea.
After a hard nights drinking, Tom woke up to the Call of Cthulhu.
by Tom Frankenberger February 24, 2003
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