Top Definition
When copious amounts of caffeinated beverages have failed to keep you sufficiently awake and alert. Oftentimes occurring in mid-afternoon and during important meetings. Sometimes can also occur late at night when operating a motor vehicle.
After falling asleep in the middle of the board meeting, Ed realized he had experienced caffeination failure when his head slammed into the conference room table.
by miss gradenko June 22, 2011

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