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1.
In a message board, when someone breaks a chain of people repeating the same phrase, it is considered a c-c-c-combo breaker.
In a topic on a message board...

n00b102: What is Doom?
1337Guy: It's a computer game.
nubkiller: It's a computer game.
sexigurl: It's a computer game.
1337one: It's a game from id software.

Moth389:C-C-C-COMBO BREAKER!!!
by DistinctlyBritish August 09, 2004
 
2.
It came from killer instinct in which you could stop someones combo right then and there hense why it is called a combo breaker which the announcer pronounces it C-C-C-C-Combo Breaker
Play KI you shall see
by Dynamo October 08, 2004
 
3.
It's an expression to say that someone changed something that had been repeated.

A bunch of white US presidents until Barack Obama broke repeated combo.

C-C-C-COMBO BREAKER!
by eleZeta November 05, 2008
 
5.
Breaking the combo on a comment board or group IM.
Anonymous: Now, this is a story all about how
Anonymous: My life got flipped-turned upside down
Anonymous: And I liked to take a minute
Anonymous: Just sit right there
Anonymous: I'll tell you how I became the prince of a town called Bel Air
Anonymous: In west Philadelphia born and raised
Anonymous: On the playground was where I spent most of my days
Anonymous: Chillin' out maxin' relaxin' all cool
Anonymous: And all shootin some b-ball outside of the school
Anonymous: When a couple of guys
Anonymous: Who were up to no good
Anonymous: C-C-C-COMBO BREAKER!
Anonymous: Asshat.

Anonymous: Old Godzilla was hoppin' around
Anonymous: Tokyo city like a big playground
Anonymous: When suddenly Batman burst from the shade
Anonymous: And hit Godzilla with a bat grenade
Anonymous: Godzilla got pissed and began to attack
Anonymous: But didn't expect to be blocked by Shaq
Anonymous: Who proceeded to open up a can of Shaq-fu
Anonymous: AND I JUST C-C-C-COMBO BROKE YOU.
by MegamanTTEX January 01, 2010
 
6.
When Barack Obama changes up a history of white presidents by being black and being the 44th President.
Dude 1: Yo, Barack Obama just got elected President by stomping John McCain!

Dude 2: C-C-C COMBO BREAKER!!!!!
by DeazKnights November 05, 2008