To think; to use one's brain; to accept the challenge to think;to wise up.
You invited your two ex-girlfriends to your party? Come on, man, brain up! What were you thinking?
by Player Monroe May 14, 2008
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You're in the midst of a breakup and feel like a different person. You find yourself spending a lot of time longing for your ex, constantly checking her Facebook updates, and wondering what went wrong. This shift in patterns of thought and behavior may be caused by neural changes that occur after a breakup.

Neuroimaging studies have found that being rejected, even by a stranger, activates many of the same regions in the brain as when experiencing physical pain. In one study, biological anthropologist Helen Fisher of Rutgers University recruited brave participants who held still in a functional MRI scanner while they looked at pictures of the person who had recently dumped them. These participants exhibited increased brain activity in several regions associated with reward, motivation, addiction and obsessive-compulsive disorder, which helps to explain why you might struggle to let go after a romantic relationship ends.
Brain brake up when you start to understand the reason behind the pain it becomes educational 😀
by ... Zjdbckdnznsjd September 22, 2019
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Break-up brain is a situation in which occurs when have just broken up with your romantic partner or significant other after a long term relationship. A person suffering from break-up brain suddenly finds every person around them attractive and has multiple concurrent crushes right after a break-up.
Ever since Maria broke up with her high school boyfriend of 2 years, she had a serious case of break-up brain - she suddenly finds everyone attractive!
by Kay97 December 1, 2016
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