Top Definition
when you become weak after struggling to be able to open a bottle. if you cant open it on the first go, you probably have bottle fatigue
"ive been trying to get this bottle of coke open for 5 minutes and my hand is raw, i've got some serious bottle fatigue", "tyra opened up the bottle immediately for me cause she did not have bottle fatigue and my attempt left my hands crippled and useless"
by wh219 May 02, 2010
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