An alternate name for HIV.
"Cedrick had to go to clinic to get tested for the Booty-Flu."
by Lt. Roastabotch July 29, 2005
HIV, the AIDS virus.
Damn, don't touch that slut, I hear she got the booty flu.
by Christopher May 29, 2006
Bootyflu also known as "the shits" or "the runs"
Heavy got the bootyflu and was stuck at home all day.
by rubberneck August 24, 2007