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1.
Any form of partying. i.e. drinking, smoking, sexing.
Hey... you gonna get boofie on Thursday night with me?" "YEAH! I can't wait to get boofie
by Party Pat May 11, 2011
 
2.
poopie
"he took a big boofie and didn't even flush the toilet!! It looked like a fish."
by tooter March 19, 2003