Originally a Dr. Dre song, but has since evolved into a generic saying used to blow off a shitty situation involoving a female. The song has since been remade by Ben Folds.
Guy: Dude, I broke up with Anna last night.

Friends: Screw her dude, bitches aint shit, lets get wasted.
by peaceoutmaw December 08, 2006
Self explanatory. Bitches(as in ho's and sluts and ugly cuntfaces) ain't(are not) shit(nothing good. stupid. smelly. ugly.
Dooby: dude wtf. girls hate me. im gonna go to mexico when no one is looking!
jeff: Bitches ain't Shit!
Dooby: :( i am robo dooby. i have no emotion.
by jeffwebb November 20, 2005

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