Top Definition
An uncomfortable and/or embarrassing emotional experience caused by observing another person's actions or witnessing an awkward situation caused by another person's actions.
He tried to get up three time to tell her that he still loved her. Unfortunately, he was too drunk. Finally her new boyfriend helped him into a cab. It was really ass-twitching.

Did you watch his latest video blog post -- the one where he talked about his childhood? He really opened up; but the part about him wetting the bed until he was 19 made my ass-twitch a little.
by kallena May 04, 2010

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