1. When one is still screwed up and unable to deal with members of the sex of their sexual preference after dumped by a true love.
2. When one is still fucked up in the head for such a prolonged period that the damaage appears permanent, so they stay at home every spare moment they have intoxicated and alone. Attempts to socialize cause more confusion or pain.
Larry was so head afterphucked by Kristal that he spent all his money on cocaine and vodka, and he couldn't do anything about it because he mistrusted everyone especially women, and couldn't deal with it in a healthy way.