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2.
You only slide once. Termed for when you go on waterslides at waterparks and perform dangerous stunts and tricks on them. This usually occurs on rather large slides, with quite a bit of height.
"Jack is about to go down that giant waterslide while standing up!"
"YOSO, Jack! YOSO!"
by Brownie724 September 13, 2012
13 12
 
1.
Your Only Squirt Once
I screamed YOSO while I jerked off in my girl's hair while she was sleeping.
by FabledPoet October 24, 2012
29 17
 
3.
The love child of "yo" and "so". Used to catch a peer's attention when one is about to say something important. Often capitalized when the shock factor of what the speaker is saying exceeds lowercase letters, becoming YOSO! When one is expressing concern or wary, they might draw the letters out to resemble "yooooossooooo". Derived from the popular comedy duo Jake and Amir. May also be used as a greeting between two friends.
Nicole: Yoso my cat threw up in the bong water.
Diana: Ugh, tits.

or

Amir: Yoso, when it snows my feet, they bleed coz my shoes have holes and I can nay afford socks'o.

or

Randall: YOSO PARTY AT MY PLACE TONIGHT!

or

Friend #1: Yoso
Friend#2: Yooosoooo I have a test tomorrow and I'm not ready!
by nicomeowmeow June 12, 2011
15 31