look up any word, like bukkake:
 
3.
You only slide once. Termed for when you go on waterslides at waterparks and perform dangerous stunts and tricks on them. This usually occurs on rather large slides, with quite a bit of height.
"Jack is about to go down that giant waterslide while standing up!"
"YOSO, Jack! YOSO!"
by Brownie724 September 13, 2012
 
1.
Your Only Squirt Once
I screamed YOSO while I jerked off in my girl's hair while she was sleeping.
by FabledPoet October 24, 2012
 
2.
You Only Stick Once. The process of hitting on multiple people knowing that you will at least hook up with one of them. The genesis of this acronym comes from the expression, "Throw enough shit against the wall and something is bound to stick."
I just tinder messaged 50 girls. At least one of them is going to be down. #yoso
by aro8888 August 20, 2014
 
4.
The love child of "yo" and "so". Used to catch a peer's attention when one is about to say something important. Often capitalized when the shock factor of what the speaker is saying exceeds lowercase letters, becoming YOSO! When one is expressing concern or wary, they might draw the letters out to resemble "yooooossooooo". Derived from the popular comedy duo Jake and Amir. May also be used as a greeting between two friends.
Nicole: Yoso my cat threw up in the bong water.
Diana: Ugh, tits.

or

Amir: Yoso, when it snows my feet, they bleed coz my shoes have holes and I can nay afford socks'o.

or

Randall: YOSO PARTY AT MY PLACE TONIGHT!

or

Friend #1: Yoso
Friend#2: Yooosoooo I have a test tomorrow and I'm not ready!
by nicomeowmeow June 12, 2011