Top Definition
You're only in college once. A reason to do anything and everything in college because you only get 4 years.
"Dude never turn down a rim job from a sorority girl, YOICO!"

"You have to get roofied sometime, it's college, YOICO!"
by gingerbreadman12863 November 05, 2013
You're Only In College Once.
I am going out tonight even though I have a test tomorrow, YOICO.
by UCFGIRL June 22, 2011

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