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1.
1) The words and actions of a socially talented person, often a salesman or aspiring actor/producer/pick-up artist, as he bounces from group to group at a particular event. Public speakers are capable of working the room without leaving the stage.

2) The seduction of an entire room of men by an attractive woman, often with the intent of sales or self-promotion.
Goofus was a wallflower all night, while Gallant was working the room.
by ATexan November 23, 2009
 
2.
In the workplace, the act of visiting colleagues at their desks and chatting to them under the pretence it's work-related to avoid doing any real labour.

Usually seen towards the end of a shift as the culprit winds down.
Charlotte: "Where's Robert?"

Dave: "He went for a cig and now he's working the room."
by Thirsty Ferret August 08, 2008