Top Definition
n. Any witty, clever, jocular, cheeky, or otherwise exceptionally intelligent being; a wag. Derivation of adj. "wit" and n. "screwball."
Conan O'Brien never ceases to shoot off those one-liners. Assuming his jokes aren't scripted by someone else, the guy is a real witball.
by Vegan Steven February 28, 2010

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