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1.
Comes from the French language, where 'yes' is said 'oui oui,' which sounds similar to 'wee wee.' To take a wicked yes is to take a wicked piss.
Family Guy-

Teacher: "In French, when youy want to say yes, you say,'Oui oui.' "

Peter: "You gotta be freakin' kidding me! What do they say for no,'doo doo?' Hey, I'll be right back, I gotta take a wicked yes."
by Reils August 18, 2006
 
2.
when u have to take a wicked piss
"ill be back i need to take a wicked yes" family guy
by quackers August 27, 2005