It means "Where Are You?" , "Art thou" was used also in Shakespeare's "O Romeo, Romeo! wherefore art thou Romeo?"

"Thou shalt" and "thou shalt not" are used in the King James version of the Bible in translating the Ten Commandments.
O Brother, Where Art Thou? means (O Brother, Where Are You?)
by shager May 1, 2015
Get the Where Art Thou? mug.
The act where Daddy Pig goes missing and you don’t know where that silly man could have gone!
Peppa: OH DADDY PIG!? daddy pig, where art thou?
by Bobbie Newtron2 acc January 11, 2021
Get the daddy pig, where art thou? mug.
Great movie starring George Clooney. It's based on Homer's Odyssey but is set in Mississippi during the depression.
The One-Eyed Bible Salesman in O Brother, Where Art Thou? is definetly polyphemus the cyclops from the Odyssey.
by Jon Reed November 25, 2006
Get the O Brother, Where Art Thou? mug.
Great movie with George Clooney, John Turturro, Tim Blake Nelsn, etc. Adventure of a few bumbling hick crooks becoming famous musicians.
Last night, I watched the movie "O Brother, Where Art Thou?"
by Traveling Bob July 30, 2006
Get the O Brother, Where Art Thou? mug.
1. When you're bored and realise you might as well get off your ass and go look for your asshole friend.

2. Something to ask your asshole friend over the cellphone when you want to meet up.

3. A great movie about by St. John the Baptist De La Salle.

4. When you sober up and realise that your asshole friend ditched you in the middle of a boring party.
1 - Shit the TV is broken. FRAAAANK?! FRAAAANK.

2 - Hey, is Zob there? Zob, that you? O Fucker, Where Art Thou? GET YOUR ASS HERE PRONTO.

3 - The joke is on you guys, the joke is on you! The uppers are leaving and so are you!

4 - Meglhlghlg. Ugh. My head. Where are my pants? FRAAAAAANK.
by General Hath January 29, 2009
Get the O Fucker, Where Art Thou? mug.