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Whats Up? 

What is happening wiht you, How are you, whats going on?
Something that LouAnn doesnt understand.

Usual response: Nothin Much
**Do not reply 'HI' or with another 'Whats Up'**

A common phrase that most people understand & use each day.
Carl: Hey Dude
Mark: Hey Whats up?
Carl: nothin much
Mark: Cool
Whats Up? by Ednabrowneye13 January 17, 2009
what's happening with you?

also lookup:
word up
sup
wizzup
hey, whats up?
whats up by actionsketch November 26, 2003
How people who are too lazy to add a single apostrophe to a word, spell the phrase, "What's up?" (What-is-up?).
Man: Hey man! Whats up! I'm so lazy that I decided to leave the apostrophe out of "what's", that way I can conserve more energy. You know, because I oppose global warming and all that.
Whats Up by Hold My Umbrella June 15, 2011
term used when you did something badass
after slapping a bitch thats "whats up"

klucthing it
whats up by benjijuice18 July 26, 2009

Whats up? 

What is happEnig friend
Whats up? by Kevin December 4, 2003
Something you say to someone who looks sad or troubled
Hey whats up, u don't look like your happy self
Whats up by 20104u January 14, 2010