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2.
Greeting meaning hello, or most likely hi, it is said in a deep tone, and with feeling.
What up do nigga!
by Terry Fields May 19, 2003
 
1.
A greeting used amongst people in urban setting. It can be used in several ways. It can express freindship,anger or a question. Used extensively in the upper east of the midwest; mainly Detroit.
(to a group of people) What up do!? (retrun answer) What up do!!
by Aristidis Alexopoulos April 02, 2007
 
3.
what up dude? what up?
What up doooooo? How it be?
by gregory j January 12, 2006