Top Definition
When a person falls into a state of extreme happiness and joy when listening, seeing or talking about anything to do with the band U2 or the lead singer Bono.
He was in a state of U2phoria when he traveled 760 miles to see U2 play in a concert.

When she listens to Bono sing she falls into a psychotic U2phoria state.
by ahlem July 02, 2011

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