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1.
A crazy person, totally wack and lost of all senses and logical thinking.
Unless it's a female, then it's a very wise and open minded person, a girl with both look and brains
Saw how that Tyrie just wacked out? Duude!

Wow, she sure is some piece of a tyrie
by Ravenpuff March 30, 2009
 
2.
A result from being irie blazed stoned high etc and tired. tired + irie = Tyrie. Originated from local San Diego stoners.
Im real Tyrie after cheefin that blunt.
by bmkracer May 17, 2007