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1.
A women who stops other women from having sex

A girl cockblocker
Girl 1 : I really like you. Do you wanna come back to my place?
Guy: sure
Girl 2 : you really shouldnt do that you know you have a boyfriend.
Girl 1 : dammit

Guy 1 : do you know Meagan

Guy 2 : yeah she has like no girlfriends

Guy 1. : I heard it's because she is a total Twot-swotter
by Pop-tart98 July 09, 2011
 
2.
a woman who stops another woman from getting laid
a twotswotter is acockblocker for women
by skinny pv July 19, 2010