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1.
Unbearably painful and traumatic physical and psychological symptoms that occur following the discontinuance of Twitter, whether voluntary (like that's going to happen) or by force.
@beverlism I clearly spend too much time tweeting my life. So, Twitter hiatus until next Monday. One super-sized serving of twithdrawal, coming up!
by Beverlism November 10, 2009
 
2.
the withdrawal felt by one when the Twitter site goes down for maintenance or if one is unavailable to check their Twitter for a long extended period of time.
Dude Twitter needs to finish their maintenance, i'm going through major twithdrawals!
by Honey to the H June 16, 2009